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He suggested it may be wise to limit access to ecigarettes to people who are actively attempting to quit smoking under a physicians guidance

Findings revealed that PLWH who smoke exhibited lower levels of neuroinflammation and better cognitive control compared to non-smoking PLWH

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Notably, P4HA1 modulates this process by regulating the -ketoglutarate/succinate axis: its upregulation under hypoxia inhibits HIF-1 hydroxylation, further preventing pVHL-mediated ubiquitination and degradation of HIF-1, while P4HA1 knockdown enhances HIF-1 hydroxylation and subsequent recognition by pVHL, accelerating HIF-1 proteasomal degradation